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Keiji Moriyama Selected Research

Acrocephalosyndactylia (Apert Syndrome)

1/2021Craniofacial, oral, and cervical morphological characteristics in Japanese patients with Apert syndrome or Crouzon syndrome.
1/2021Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W/+ ) mouse model.
11/2018Maldevelopment of the submandibular gland in a mouse model of apert syndrome.
1/2014Therapeutic effect of nanogel-based delivery of soluble FGFR2 with S252W mutation on craniosynostosis.
9/2012Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts.
10/2004A soluble form of fibroblast growth factor receptor 2 (FGFR2) with S252W mutation acts as an efficient inhibitor for the enhanced osteoblastic differentiation caused by FGFR2 activation in Apert syndrome.

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Keiji Moriyama Research Topics

Disease

6Craniosynostoses (Craniosynostosis)
01/2021 - 08/2003
6Acrocephalosyndactylia (Apert Syndrome)
01/2021 - 10/2004
4Cleft Lip (Harelip)
03/2019 - 05/2004
4Cleft Palate (Palate, Cleft)
03/2015 - 11/2009
3Syndactyly (Polysyndactyly)
01/2021 - 10/2004
3Bone Resorption
01/2013 - 09/2002
3Periodontitis
01/2013 - 07/2009
2Anodontia (Hypodontia)
08/2021 - 05/2004
2Synostosis
01/2021 - 01/2014
2Craniofacial Dysostosis (Crouzon Disease)
01/2021 - 10/2011
2syndromic 2 Microphthalmia
12/2018 - 10/2015
2Congenital Abnormalities (Deformity)
03/2017 - 08/2003
2Hypoxia (Hypoxemia)
11/2013 - 07/2009
2Marfan Syndrome (Marfan's Syndrome)
01/2013 - 07/2009
1Lymphangioma (Cavernous Lymphangioma)
06/2021
1Bites and Stings (Sting)
01/2021
1Pain (Aches)
01/2021
1Prognathism
08/2020
1Seizures (Absence Seizure)
11/2019
1Osteoarthritis
06/2019
1Dental Caries (Decay, Dental)
03/2019
1Malocclusion (Crossbite)
01/2018
1Squamous Cell Carcinoma of Head and Neck
03/2016
1Chromothripsis
03/2016
1Wolf-Hirschhorn Syndrome
03/2015
1Neurofibromatoses (Neurofibromatosis)
11/2014
1Osteoporosis
08/2014
1Fibrosis (Cirrhosis)
02/2014
1Chronic Periodontitis
01/2013
1Aortic Aneurysm (Aneurysm, Aortic)
01/2013
1Infections
01/2013
1Intellectual Disability (Idiocy)
03/2012
1Facial Asymmetry
01/2012
1Stomatognathic Diseases (Dental Disease)
08/2011
1Root Resorption
08/2011
1Beckwith-Wiedemann Syndrome (Exomphalos Macroglossia Gigantism Syndrome)
04/2011
1Cicatrix (Scar)
11/2009
1Silver-Russell Syndrome
10/2009
1Mitral Valve Prolapse
07/2009
1Ectopia Lentis
07/2009
1Wounds and Injuries (Trauma)
03/2007
1Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
11/2006
1Type 1C Limb-Girdle Muscular Dystrophy
11/2006
1Muscular Atrophy (Muscle Atrophy)
11/2006

Drug/Important Bio-Agent (IBA)

5Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA
01/2021 - 10/2004
3Messenger RNA (mRNA)IBA
12/2018 - 10/2004
3Proteins (Proteins, Gene)FDA Link
11/2013 - 08/2011
3Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
09/2012 - 08/2003
2DNA (Deoxyribonucleic Acid)IBA
08/2021 - 03/2016
2NucleotidesIBA
11/2019 - 11/2018
2Estrogens (Estrogen)FDA Link
06/2019 - 05/2004
2Co-Repressor ProteinsIBA
12/2018 - 10/2015
2Insulin (Novolin)FDA Link
08/2014 - 02/2014
2CC ChemokinesIBA
07/2009 - 09/2002
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2007 - 09/2005
2OsteopontinIBA
02/2007 - 10/2004
2MyostatinIBA
11/2006 - 04/2002
1CateninsIBA
01/2021
1A-factor (Streptomyces)IBA
01/2018
1Protons (Proton)IBA
03/2016
1Tretinoin (Retinoic Acid)FDA LinkGeneric
03/2015
1Histone MethyltransferasesIBA
03/2015
1SolutionsIBA
11/2014
1Peptides (Polypeptides)IBA
08/2014
1Peptide Hormones (Polypeptide Hormones)IBA
02/2014
1RelaxinIBA
02/2014
1Hormones (Hormone)IBA
02/2014
1NanogelsIBA
01/2014
1Therapeutic UsesIBA
01/2014
1polyethylene glycol polyethyleneimine nanogelIBA
01/2014
1Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
11/2013
16- (2- tert- butyl- 5- (6- methylpyridin- 2- yl)- 1H- imidazol- 4- yl)quinoxalineIBA
11/2013
1PeriostinIBA
11/2013
1Small Interfering RNA (siRNA)IBA
11/2013
1Pharmaceutical PreparationsIBA
01/2013
1Angiotensin Receptor AntagonistsIBA
01/2013
1Telmisartan (Micardis)FDA Link
01/2013
1CytokinesIBA
01/2013
1AmelogeninIBA
08/2011
1hydrogen sulfite (bisulfite)IBA
10/2009
1Fibrillin-1IBA
07/2009
1LigandsIBA
07/2009
1ChemokinesIBA
07/2009
1Complementary DNA (cDNA)IBA
07/2009
1Oxygen (Dioxygen)IBA
07/2009
1OligonucleotidesIBA
03/2007

Therapy/Procedure

6Distraction Osteogenesis
03/2017 - 08/2003
3Therapeutics
06/2021 - 11/2005
2Sutures (Suture)
01/2021 - 01/2014
2Osteotomy
11/2012 - 01/2012
2Bone Transplantation (Bone Grafting)
05/2004 - 08/2003
1Dental Occlusion
01/2021
1Retreatment
01/2021
1Orthognathic Surgery
08/2020
1Oral Hygiene (Dental Hygiene)
03/2019
1Operative Surgical Procedures
01/2014
1Sagittal Split Ramus Osteotomy
01/2012
1Glossectomy
04/2011
1Bone Lengthening
05/2010
1Lasers (Laser)
11/2009